Objective To imvestigate transcranial Doppler (TCD) and color Doppler flow imaging (CDFI) changes of hemodynamics of subclavian artery lesions and clinical value of combined evaluation. Methods A retrospective analysis of 45 cases of clavicle by TCD and CDFI combined detection of artery (SA), according to the SA CDFI test results were divided into mild stenosis (stenosis <50%); moderate stenosis (50% ~ 69%), severe stenosis and occlusion (70 - 99% (100%) of four groups, and each test results and TCD detection of intracranial artery steal degree (divided into vertebral artery not steal, stage I steal, steal and stage II III steal four groups) were analyzed. Analysis of CDFI and TCD detected the midrib pressure difference value. Results No steal steal, phase I, phase II and III steal steal four groups of patients with double upper limbs blood pressure difference were 5.8 + 3.1, 13.6 + 9.2 and 28.2 + 13.2 and 39.3 + 10.2mmHg. There was significant difference in the comparison between the groups (p<0.01); mild stenosis, moderate stenosis, severe stenosis and occlusion of four groups of patients with double upper limbs blood pressure difference were 7.9 + 4.7, 20.6 + 10.2 and 32.8 + 13.2 and 40.6 + 16.2mmHg. There was significant difference in the comparison between the groups (p<0.01). TCD examination of 8 cases of patients with no steal in CDFI showed 6 cases, mild stenosis, moderate stenosis in 2 cases; TCD examination in 21 cases of stage I steal patients, CDFI showed mild stenosis in 12 cases, moderate stenosis in 9 cases; TCD examination in 11 cases of stage II steal patients, CDFI showed moderate stenosis in 3 cases, severe stenosis in 7 cases; 1 cases of occlusion; TCD examination in 5 cases of stage III steal patients, CDFI showed 3 cases of severe stenosis and occlusion in 2 cases. Conclusion The patients of upper limbs pulse pressure size can be preliminarily reflect severity and vertebral artery SA steal degree. TCD and CDFI for detection of SA lesions are highly related, the combined detection of TCD and CDFI, can observe the changes of the diameter of SA, vascular, change of hemodynamics and intracranial and extracranial compensatory blood flow, contribute to the clinical comprehensive evaluation.