Objective To study the clinical effects of continuous and intermittent blue light irradiation in the treatment of neonatal jaundice. Methods From Jun. 2013 to Feb. 2015, a total of 64 neonates with jaundice in our hospital were taken as the clinical research objects, and they were randomly divided into A group (32 cases) and B group (32 cases). All the patients accepted conventional treatment, besides, patients in the A group were given intermittent blue light irradiation, and the other patients in the B group received continuous blue light irradiation. The physical signs and mental status of the two groups were observed, and the improved symptoms of jaundice and adverse reactions were recorded. Results There was no significant difference in total effective rate between A group (intermittent group) and B group (continuous group) (93.75% vs 96.87%,P>0.05), the incidence of adverse reactions in A group (intermittent group) was lower than that in B group(continuous group), and their difference was statistically significant (34.38% vs 46.88%, P<0.05). Conclusion Both continuous and intermittent blue light irradiation have significant effects on neonatal jaundice, meanwhile, the intermittent blue light irradiation can greatly reduce the incidence of adverse reactions.