Objective To study the effect of integrated emergency nursing mode on the treatment of patients with acute cerebral infarction. Methods Our hospital began to implement integrated emergency nursing mode from January 2015. 67 patients in 2015 as observation group were treated with integrated emergency nursing mode. 67 patients in 2014 as control group were treated with routine emergency nursing. The thrombolytic waiting time, neurological deficit score(ESS), daily living ability (Bather index) and clinical efficacy were compared. Results There was no significant difference in ESS and Bather scores of the two groups before intervention (P>0.05). The thrombolytic time, ESS and Bather scores of the observation group were better than those of the control group. The difference was statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the control group. It was statistically significant(P<0.05). Conclusion The implementation of integrated emergency nursing mode makes the emergency procedure of acute cerebral infarction more standardized. It can be used and popularized in clinic because of treatment efficacy, shorten treatment time, improving neurological function and daily life ability.