Objective To analyze and discuss the clinical application of multi-slice spiral CT (MSCT) in the diagnosis of nutcracker syndrome. Methods 60 cases of nutcracker syndrome were selected from August, 2013 to May, 2016, and 100 normal subjects were selected as group A and group B respectively. The MSCT findings and the accompanying signs of LRV (left renal vein) in group A were compared with those of the two groups. The angle between SMA (superior mesenteric artery) and AA (abdominal aorta) AA and LRV, the ratio of the cross-sectional area (C1) of the LRV to the compression point of the proximal end of the LRV, and the cross-sectional area (C2) of the proximal part of the proximal renal region were calculated. The statistical analysis was performed. Results In group A, 5 cases showed left renal enlargement, 5 cases showed slow perfusion of left kidney, 14 cases showed collateral circulation, and 60 patients showed LRV funnel-like lesions. The data of the two groups were compared, there were differences, statistically significant (P<0.05). Conclusion MSCT examination can clearly reflect the specific morphology of LRV, and can accurately measure the data, extremely intuitive to determine the narrowing of the LRV compression site, and can observe the nutcracker syndrome associated with signs, thereby enhancing the disease Diagnostic accuracy.