Objective To explore the low pressure pulse air enema with different gas injection pressure for the treatment of intussusception in children of different age effect. Methods In our hospital from January 2016 to July 2016, 117 cases of infantile intussusception during the treatment of income as the object of study, all patients were treated with low pressure pulse air enema therapy, and to observe the therapeutic effect of the application of different gas injection pressure. Results Through the observation of research data shows that in this study the successful treatment of 95 cases, 22 cases for treatment failure, the cure rate is 81.19%, the visible reduction pressure of 12-14kpa when the success probability is higher, the probability of success and the rest of the gas injection pressure comparison, the difference was statistically the significance of existence (P<0.05). Conclusion Low pressure pulse air enema in the treatment of children's intussusception can achieve a higher success rate, but should be considered in the actual disease to choose the gas injection pressure suitable in practical application, in order to give full play to its therapeutic value.