Objective To investigate the clinical effect of low temperature plasma radiofrequency ablation in the treatment of chronic hypertrophic rhinitis. Methods 53 cases of patients with chronic hypertrophic rhinitis treated in our hospital from March 2012 to March 2016 were selected. The patients were treated with radiofrequency ablation for low temperature plasma radiofrequency ablation. Inferior turbinate lesions score, VAS score and saccharin test 6 months before and after surgery. Results Postoperative inferior turbinate lesions score (1.09+0.29) was significantly lower than that before operation (2.83+0.38), postoperative VAS score (3.09+0.68) was significantly lower than that before operation (8.04+0.55), there was significant difference between two groups (P<0.05), nasal mucosa cilia movement rate before operation for (7.07+0.64) mm/min after surgery (6.99+0.74) mm/min, there was no significant difference (P>0.05). Conclusion Low temperature plasma radiofrequency ablation in the treatment of chronic hypertrophic rhinitis, less bleeding, rapid recovery of the wound surface, can better protect the physiological function of the nasal mucosa, the curative effect is remarkable, it is worthy of clinical application.