Objective To observe the clinical results of budesonide combined with terbutaline and ipratropium bromide inhalation for asthma. Methods A total of 86 children with asthma admitted to our hospital from February 2017 to March 2018 were randomly divided into two groups according to the digital table method. 43 patients in the control group were given budesonide combined with terbutaline inhalation. Forty-three patients in the observation group were given ipratropium bromide atomized inhalation on the basis of the control group, and the clinical effects after treatment were compared between the two groups. Results The total effective rate of the observation group was 95.35%, which was significantly higher than that of the control group(63.79% (χ2 =13.7712, P=0.0000). The disappearance time and hospitalization time of asthma, cough and wheezing in the observation group were significantly shorter than that of the control group. (T=2.1735, 3.0986, 2.7142, 2.2106, P<0.05, respectively), FVC, FEV1, FEV1/FVC were significantly increased in both groups, and the observation group was significantly higher than the control group after treatment (t=1.9758, 2.1642, 8.4136, P<0.05). Conclusion Budesonide combined with terbutaline and ipratropium bromide inhalation in children with asthma is effective, can effectively reduce the body's inflammatory response and improve lung function, significantly shorten the disappearance of clinical symptoms, it is worthy of clinical application.