Objective To explore clinical effect of ultrasonic elastography combined with color Doppler ultrasound in diagnosis of breast mass. Methods 78 cases of patients undergoing breast mass diagnosis in our hospital from September 2015 to July 2016 were selected, and each patient was undergoing color Doppler ultrasound and ultrasonic elastography in turns, and the result was compared with pathological findings after operation. Results Among 65 cases of benign masses, the coincidence rate was 93.85% of ultrasonic elastography combined with color Doppler ultrasound. There was no blood flow or a small amount of blood flow in the mass, accounting for 78.46%, and the elasticity score 1-2 of the mass, accounting for 87.69%. In postoperative pathology diagnosis, there were 13 cases of malignant tumor patients, and coincidence rate was 92.31% of ultrasound elastography combined with color Doppler ultrasound, and mass flow richer or abundant accounted for 69.23%, mass elastic score 3-5, accounting for 84.62%. Conclusion Ultrasonic elastography combined with color Doppler ultrasound can significantly improve diagnostic accuracy of benign and malignant breast lumps.