Objective To study the effects of nursing risk factors analysis on unscheduled interruption time of ICU patients undergoing continuous renal replacement therapy. Methods 60 patients in the intensive care unit(ICU) of our hospital who were treated with continuous renal replacement therapy(CRRT) were selected and randomly divided into observation group and control group, with 30 cases in each group. Control group was given routine nursing, and observation group was given risk factors analysis and nursing on this basis, and they were nursed until normal discharge. The pipeline use time, ICU stay and unscheduled interruption time were observed in the two groups after nursing intervention, and the frequency and reasons of unscheduled interruption during nursing were counted in the two groups. Results The pipeline use time in observation group was higher than that in control group(P<0.05). The ICU stay and the number of cases of unscheduled interruption in observation group were lower than those in control group(P<0.05). The frequency of unscheduled interruption in observation group was lower than that in control group (P<0.05). The high transmembrane pressure and the frequency of grade II or III coagulation occurred in filter were similar in the two groups(P>0.05), and the number of interruption which could not rule out the alarm reason in observation group was lower than that in control group (P<0.05). Conclusion Nursing risk factors analysis for ICU patients undergoing continuous renal replacement therapy is mainly to shorten unscheduled interruption time by reducing frequency of unscheduled interruption.