Head and Neck Imaging
Effect of Gabapentin on Hemodynamic Status and PKC Levels in Patients with Migraine
Author：WANG Hong-liang
affiliation：Department of Neurology, Luoyang Oriental Hospital, Luoyang 471003, Henan Province, China
PDFAbstract
Objective To observe the effect of Gabapentin (GBP) on hemodynamic status and protein kinase C (PKC) levels in patients with migraine. Methods 78 migraine patients were randomly divided into GBP group (study group, n=39) and flunarizine group (control group, n=39). The mean velocities (Vm) of left (L) and right (R) anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA) in the two groups were detected before treatment(T1) and 1 month after treatment(T2), the plasma PKC levels in the two groups were tested, and the degrees of headache [Short-form McGill Pain Questionnaire-2 (SF-MPQ-2)] in the two groups were also assessed. Results At the time of T2, the levels of Vm and plasma PKC, and SF-MPQ-2 scores of LACA, RACA, LMCA, RMCA, LPCA and RPCA in the two groups were all lower than those at T1, and the change ranges in the study group were lower than those in the control group (P<0.05). Conclusion Gabapentin which is beneficial to the prognosis of patients, can improve hemodynamic status, inhibit central sensitization, and effectively relieve pain of migraine patients.
【Keyword】Gabapentin; Migraine; Hemodynamic Status; Protein Kinase C
【Chart number】R972+.6；R747.2
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2019.01.002
Journal of Rare Diseases
th26Volume， th 1 Issue
2019Year01Month
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