Objective To explore the effects of maternal-infant bedside nursing model on the risk of postpartum depression in primiparae. Methods A total of 150 primiparae who were given normal delivery in our hospital from October 2016 to December 2017 were selected and divided into experimental group and control group according to the random lottery method. Control group was given routine maternal-infant nursing, and experimental group was given maternalinfant bedside nursing model. The postpartum feeding methods of puerperae were observed in the two groups, and the incidence rate of postpartum depression and satisfaction towards nursing work were counted. Results The success rates of breastfeeding in the two groups were 96.00% and 86.67% respectively, and the success rate of breastfeeding in experimental group was significantly higher than that in control group (P<0.05). The incidence rates of postpartum depression in the two groups were 5.33% and 18.67% respectively, and the incidence rate in experimental group was significantly lower than that in control group (P<0.05). The nursing satisfaction rates were 93.33% and 82.67%, respectively, and the rate in experimental group was significantly higher than that in control group (P<0.05). Conclusion Maternal-infant bedside nursing model can significantly improve the success rate of breastfeeding, and reduce the risk of postpartum depression, and it has high maternal satisfaction.