Objective To observe the application of high quality nursing in the perioperative period of extracranial-intracranial anastomosis in stroke patients. Methods A total of 52 patients with stroke who underwent extracranial-intracranial anastomosis in the inpatient department of our hospital from January 2016 to December 2016 were selected and randomly divided into control group and observation group, with 26 cases in each group. Control group was given routine nursing, and observation group was treated with high quality nursing. The differences of different nursing prognosis, psychological status (self-rating depression scale score, Hamilton anxiety scale score) and nursing satisfaction were compared between the two groups. Results After intervention, the self-rating depression scale (SDS) score and Hamilton anxiety scale (HAMA) score in the two groups were lower than those before intervention, and the self-rating depression scale (SDS) score and Hamilton anxiety scale (HAMA) score after intervention in observation group were lower than those in control group (P<0.05). The nursing satisfaction rate in observation group was significantly higher than that in control group (88.46% vs 76.92%) (P<0.05). Conclusion High quality nursing in the perioperative period of stroke patients is conducive to the health recovery of patients.