Objective To investigate the dual-source CT perfusion imaging(CTPI) features of hepatocellular carcinoma(HCC), hepatic hemangioma and Focal nodular hyperplasia(FNH) and its diagnose value. Methods CT perfusion scans were performed with dual-source CT in 10 HCC patients, 8 hepatic hemangioma patients and 8 FNH patients, perfusion parameter of center and edge of lesions, normal liver tissue were collected and analyzed. Results The values of blood flow(BF), blood volume (BV), Hepatic arterial perfusion(HAP)were higher than normal liver tissue in HCC group, hepatic hemangioma group and FNH group(P＜0.05), The values of BF, BV was the highest for FNH group, followed by HCC group, hepatic hemangioma group(P＜0.05), There were no statistical differences between the values of BF, BV in HCC group and hepatic hemangioma group(P＞0.05), but both significantly lower than FNH group(P ＜0.01). The values of time to start(TTS), time to peak(TTP) were significantly lower than normal liver tissue in HCC group and FNH group(P＜0.05), but significantly higher than normal liver tissue in hepatic hemangioma group, the values of TTS, TTP was the highest for hepatic hemangioma group, followed by HCC group, FNH group(P＜0.05). The values of permeability of surface area product(PS) were higher than normal liver tissue in HCC group and FNH group, but were no statistical differences in hepatic hemangioma group(P＞0.05), the values of PS was the highest for FNH group, followed by HCC group, hepatic hemangioma group(P＜0.05). Conclusion Dual-source CTPI can provide much more information about the hemodynamics, blood supply and distribution features of HCC, hepatic hemangioma and FNH, which is helpful in differential diagnosing and clinical value.