Objective Study on MRI scan and the application of enhanced scanning in the diagnosis of Multiple Sclerosis. Methods From January 2014 to December 2015, review analysis the hospital receiving inspection data of 33 patients with multiple sclerosis, through the analysis of the MRI scan and enhanced scan multiple sclerosis lesions imaging characteristics, and analyze the characteristics of multiple sclerosis lesions, and compare the clinical features. Results This article total statistics 33 patients, MRI scan and enhanced scan showed Multiple Sclerosis lesions ranging from 3-20 mm in diameter, lesions irregular group with more than 167, distribution of 17 cases with lateral ventricle around 73;13 cases of patients with multiple sclerosis lesions distribution in deep brain white matter there are 33. Seven cases of lesions brain stem, basal ganglia region, and there are 21 bilateral cerebellar hemisphere. The lateral ventricle lesions perpendicular to the long axis of the lateral ventricle is low T1 signal and T2 and FLIAIR high signal, lesion boundaries clear. Enhanced scanning visible brain stem and lateral ventricle lesions, and part of the lesions were enhanced and parts not. Conclusion Common clinical features of multiple sclerosis and changeful, main show is the brain stem, nerve damage and other symptoms.With the rapid development of MRI techniques in clinical medical, should pay attention to the diagnosis of multiple sclerosis combined with MRI imaging techniques, through summarizing the characteristics of multiple sclerosis imaging to improve the diagnosis accuracy of MS.MRI imaging data provide the basis for the diagnosis of MS.