Objective To study the characteristics and value of MRI scan and enhanced scan in heterotopic gray matter, and to improve the performance and clinical features of gray matter. Methods The clinical and imaging findings of 10 patients with heterotopic gray matter confirmed by surgery and pathology from September 2009 to 2012 were analyzed retrospectively. All patients underwent MRI plain scan and enhanced scan. Results The brain gray matter heterotopia patients MRI diagnosis results are as follows, T1, T2, flair axial visible quadrigeminal cistern partial left occipital lobe group piece like mixed signal, lesions were ill defined, inhomogeneous signal. MRI plain scan IRT1 sequence visible quadrigeminal cistern partial left occipital lobe lesions showed more obvious; MRI plain scan eDWI sequence showed signal, no restricted diffusion. The diagnosis rate of MRI plain scan was 90%. MRI scan axial, coronal, sagittal, visible partial quadrigeminal cistern left occipital lobe lesion showed no enhancement. The diagnostic rate of MRI enhanced scan was 100%. The diagnostic rate of MRI enhanced scan was higher than that of MRI plain scan, and the difference was not statistically significant compared with the results of clinical pathology. Conclusion MRI features of heterotopic gray matter in the brain, MRI has a very high value in the diagnosis of brain gray matter, and can be used as an important examination method of gray matter in the brain.