Objective To explore application value of multisliecs helieal CT multi phase enhanced scan in the diagnosis of renal cell carcinoma. Methods A retrospective analysis of imaging data of CT scan and multiphase enhanced scan was carried out in 48 patients with renal cell carcinoma confirmed by operation and pathology in our hospital from April 2013 to May 2015, the results were compared with clinical and pathological data. Results Total accuracy rate of CT in the diagnosis of renal cell carcinoma staging was 89.58% (43/48). CT arterial phase scanning CT value was significantly higher than plain scan, parenchymal phase scanning, there was a significant difference in plain scan, parenchymal phase scanning in these groups (P<0.05). CT scan showed that 43 cases had prominent renal contour lesions, and lesions in 5 cases were confined to the renal contour. Plain scan density was more complex, 2 cases of hemorrhage showed high density shadow, 5 cases were complicated with cystic change, hemorrhage, 4 cases of calcification. There were moderate enhancement and obvious enhancement in different degrees in arterial phase, clear boundary could be seen in 40 cases after enhancement in arterial phase, pseudocapsule could be seen in 28 cases, close needling sign in 17 cases, enhancement degree was significantly reduced in kidney parenchymal phase scan, enhancement degree in venous phase was further reduced. Conclusion Multisliecs helieal CT multiphase enhanced scan has higher application value in the diagnosis and stage of renal cell carcinoma.