Objective To investigate the ultrasound contrast-enhanced MRI and high intensity focused ultrasound for assessment (HIFU) ablation treatment of uterine fibroids. Methods A retrospective analysis of our hospital 60 cases of HIFU treatment of uterine fibroids (myoma 60) clinical medical records, and before and after treatment 1 d respectively MRI, ultrasound imaging. Statistical two sets of image quality scores before and after treatment fibroid volume and so on. Results Enhanced MRI image quality score, patients without perfusion volume and average ablation rate was (3.9±0.3) points, (81.9±82.7) cm3 , (80.7±18.4)% and ultrasound contrast (2.0±0.7) points , (65.7±66.1) cm3 , (71.5±19.4)%, the difference was statistically significant, P<0.05, enhanced MRI fibroids total score of 114 points image display ultrasound contrast significantly higher than 62 points, the difference was statistically significant, P<0.05. Applications enhanced MRI scan can clearly show the relationship between fibroids border, size and with the surrounding tissue; however ultrasound contrast display blurry boundary, 10 patients could not be determined fibroids border. Conclusion Enhanced MRI can better assess the extent of HIFU ablation treatment of uterine fibroids, thus providing a strong basis for the selection of clinical prognosis and treatment options.