Objective To observe the evaluation of early chemoradiothempy efficacy in uterine cervical cancer by the different b-value ADC images. Methods 40 patients with middle and advanced stage uterine cervical cancer in stage IIb-IVa were recruited and received 4 conventional MRI and DWI exams before treatment, after 2-3 weeks , 3 times after intracavitary irradiation treatment and after treatment.The patients were divided into complete remission(CR)group(24 cases), partial remission(PR)group(16 cases)according to the changes in tumor size after 8 months of treatment. The tumor size and apparent diffusion coefficient(ADC)of uterine cervical cancer were measured at each examination among the 2 groups. According the receiver operating characteristic(ROC)curve, chemoradiotherapy efficacy and prognosis value of different b-value of ADC images in uterine cervical cancer were compared. Results There were no significant differences of the tumor shrinking rate after 2-3 weeks and 3 times after intracavitary irradiation treatment in the 2 groups(P>0.05). After 2-3 weeks treatment, at b=0,200, 0,400, 0,600, 0,800, 0,1000 s/mm2 ADC images, ROC area under curve was 0.844、0.833、0.948、 0.950, 0.958, sensitivity Was 66.7％, 75％, 83.3％, 84.5％, 91.7％, specificity was 100％, in 3 times after intracavitary irradiation treatment, at b=0,200, 0,400, 0,600, 0,800, 0,1000 s/mm2 ADC images, ROC area under curve was 0.885, 0.802, 0.948, 0.949, 0.974, sensitivity Was75％, 75％, 85％, 83.3％, 91.8％, specificity was 100％. Conclusion When evaluating the early chemoradiothempy effect of cervical cancer, High value(b=0, 600, 0, 800, 1000 s/mm2 ) are better than lower b value(b=0, 200, 0, 400 s/mm2 ).