Objective To explore effects of MRI imaging changes on the psychological status of patients with cervical cancer before and after chemotherapy and nursing intervention measures. Methods 57 cases of cervical cancer patients diagnosed by clinical pathology were selected, all patients underwent neo-adjuvant chemotherapy, MR plan scan and diffusion weighted imaging (DWI) were performed before and after 2 cycles of chemotherapy. Results DWI before chemotherapy was inhomogeneous high signals, the correlative ADC map was most in cyan area; after chemotherapy, 11 cases of lesions without residual, DWI low signal, blue area of the correlative ADC map reduced; 36 cases of decrease of tumor volume, DWI high signal, the correlative ADC map was most in green or reseda area, there was no significant difference between DWI and ADC map before and after treatment in 9 cases. After chemotherapy, ADC value in the effective group was significantly higher than the non-responders, score of symptom checklist 90 (SCL-90) subtype was significantly lower than non-responders (P＜0.05). Conclusion DWI and ADC value can predict the effect of chemotherapy on cervical cancer, but patients without significant imaging changes will be accompanied by negative emotions, and they need to be given active nursing intervention.