Objective To study the application value of CT cerebral perfusion imaging(CTP) in Transient ischemic attack(TIA). Methods Fifty-five cases of transient ischemic attack from April 2013 to April 2015 in our hospital were collected as research subject, all of them were performed CTP, CTA(CT angiography) in 24 hours after onset and MRI(Magnetic Resonance imaging) and MRA(Magnetic Resonance angiography) in 72 hours. The inspection results of CTA and MRI and CTP were compared, and the parameters of CTP like time to peak(TTP), mean transit time(MTT), cerebral blood flow(CBF), cerebral blood volume(CBV) were analyzed and compared between lesion side and healthy side. Results Thirty-five lesions were checked out by CTA inspection, 44 lesions by MRI, and 59 lesions by CTP. The detection rate of CTP was higher than that of CTA and MRI, and it was significantly different (P<0.05). 12 lesions were checked out in I1 period by CTP, 29 in I2 period, 11 in II1 period and 7 in II2 period, the lesions of I2 were significantly more than the other period, and it is statistically different (P<0.05), the value of TTP, MTT, CBF and CTP between the lesion and Health side was significantly different (P<0.05), the CBV value of CTP between the lesion and Health side had no significant difference (P>0.05). Conclusions The CTP inspection can make a comprehensive diagnosis for transient ischemic attack and offer reliable basis for its treatment.