Objective This paper is to investigate the clinical characteristics of CT examination on patients with traumatic brain injuries at acute stage and to explore its correlation with serum NT-proBNP. Methods Sixty eighty patients with acute traumatic brain injuries admitted by the Neurosurgery Department of the Hospital were selected. All patients underwent CT scanning and plasma NT-proBNP peptide level detections, and Spearman software was applied to analyze the correlation. Results The comparison in serum NT-proBNP peptide levels of patients with subarachnoid hemorrhage and no subarachnoid hemorrhage were significantly different(P<0.05). The difference of serum NT-proBNP peptide levels in patients with heavy, medium and mild brain swelling was significant (P<0.05). The difference of serum NT-proBNP peptide levels in patients of I, II and III stage traumatic brain injury was significant(P<0.05).The results of correlation analysis showed subarachnoid hemorrhage (r=6.78), cerebrum swelling degree (r=9.10) and CT classification of cerebral hemorrhage (r=8.14) were positively correlated to serum NT-proBNP. Conclusion CT is capable of reflecting subarachnoid hemorrhage in patients with traumatic brain injuries, brain swelling, making classification of brain injury. The above clinical indexes are positively correlated with serum T-proBNP, and the level of serum NT-proBNP may be evaluated according to the features of CT on patients with traumatic brain injuries, which provides accurate basis for clinical operations and prognosis.