Objective To investigate the values of Low-dose unenhanced 64-slice CT for the epicardial adipose tissue in the myocardial infarction patients. Methods From July 2011 to August 2014 ,90 myocardial infarction patients in our hospital were examined by low-dose unenhanced 64-slice CT to assess obstructive atherosclerosis, while measured epicardial fat thickness general information and kept the clinical records. Results 60 patients of the non-blocking atherosclerosis, 30 patients of obstructive atherosclerotic were finally confirmed in 90 patients with myocardial infarction, the gender, age, BMI, TG, TC, LDL, HDL and fasting blood glucose of the two were no differences in contrast statistically significant (P>0.05). Blocking atherosclerosis in patients with epicardial fat thickness were 5.67 ± 1.23mm, while obstructive atherosclerotic patients were 9.24 ± 1.46mm, epicardial fat thickness obstructive atherosclerosis in patients with atherosclerosis was significantly higher than that of non-blocking sclerosis patients (P<0.05). Logistic regression analysis showed that epicardial fat thickness was the independent risk factor for atherosclerosis obstruction and was positively correlated (P<0.05). Pearson correlation analysis showed that epicardial fat thickness and age, fasting blood glucose, TG was positively correlated; and HDL-C was negatively correlated (P<0.05). Conclusion Lowdose unenhanced 64-slice spiral CT evaluation can effectively evaluate the thickness of the myocardial infarction patients with obstructive epicardial adipose tissue atherosclerosis. Epicardial adipose tissue is an important risk factor for obstructive atherosclerosis of myocardial infarction, which is also affected by a number of clinical factors.