Objective To compare the clinical value of ultrasound contrast and enhanced CT scan in differential diagnosis of hepatic lesions. Methods A total of 60 patients of hepatic lesions which admitted into the hospital during March 2012 to March 2015 were selected as the research objects radomly. All patients underwent ultrasound contrast and enhanced CT scan and were compared with pathological findings. The application value of ultrasound contrast and enhanced CT scan in the diagnosis of hepatic lesions was analyzed. Results The ultrasound contrast parameters like RT, TTP and mTT of patients with hepatic benign lesions were higher than those of patients with hepatic malignant lesions while PI index was lower than that in the malignant lesion group. The contrast differences in ultrasound contrast parameters between benign and malignant lesions were statistically significant (P<0.05). Patients with hepatic malignant lesions mainly showedⅠtype curve shapes while various benign lesions mainly showedⅡ-Ⅲ type curve shapes. The diagnostic sensitivity and coincidence rate of ultrasound contrast were 90.5% and 95.0%, respectively. Compared with enhanced CT scan, the difference was statistically significant (P<0.05). Conclusion Ultrasound contrast can reflect the imaging information of hepatic lesions in terms of morphology, changes of dynamic curve, and data measurement. The dianostic coincidence rate is high. It and is worth to be popularized.