Objective To investigate the application value of CT multi-phase enhance scanning in diagnosis and identification of liver space-occupying lesions. Methods Fifty six patients (72 lesions) with liver space-occupying lesions admitted the Radiology Department of the Hospital were selected as research subjects, who were divided into the control group and the observation group with 28 cases in each group according to the sequence of diagnosis and treatment. Patients in the control group were subject to CT scan, and patients in the observation group were subject to multiphase dynamic CT scan, pathological examination results were treated as gold standards, and clinical diagnostic accuracy of patients in two groups were compared and analyzed. Results The positive rate of CT scan was 50.0%, and there was significant difference when compared to pathologic examination results (P<0.05). The positive rate of CT multi-phase enhance scanning of patients in the observation group was 92.9%, and there was no significant difference when compared to pathological diagnosis (P>0.05). The diagnostic accuracy of patients in the observation group was obviously higher than that of patients in the control group, and the difference was significant (P<0.05). Conclusion CT multi-phase enhance scan delivers high diagnosis value on liver space-occupying lesions, it can significantly improve clinical diagnostic rate, avoid the occurrence of lesion misdiagnosed, and impose enhanced role of information, be qualified for providing important reference basis for clinical diagnosis and treatment.