Objective To study the application value of CT diagnosis of giant uterine leiomyomas. Methods A total of 67 patients confirmed of giant uterine leiomyomas admitted in to the hospital during December 2011 to September 2014 were selected as the research objects. The GE LightSpeed 64-row spiral CT were used for detection. Among the 67 cases of patients, there were 44 cases of patients who only received plain scan and 23 cases received plain scan combined with dual-phase enhanced scan. The images were later analyzed through GE ADW4.4 workstation, mainly to observe the lesion location, morphology and density of tumors. Results There were 19 cases of uterine leiomyomas located below serous membrane, 15 cases in cervical muscle and 33 cases in muscular wall. Single lesion was found in 37 cases and multi-lesions in 30 cases including 14 patients without confirmed sites of leiomyoma. Fifty cases with clear lesion boundaries and 16 cases with unclear boundaries. The shapes of leiomyoma included irregular shape (3 cases), lobulated(3 cases), oval shape(14 cases) and round shape(31 cases). The deformity and displacement of uterine cavity in 21 cases of patients was relatively fuzzy. The growth of 30 cases of tumors exceeded the height of the pelvis A total of 15 cases showed homogeneous masses with the density of 35-60Hu, and 32 patients showed heterogeneous masses. Among the 23 patients who received enhanced scan, there were 21 cases manifesting as uneven and severe enhancement, with visible small blood vessel shadow. Conclusion CT scan is of high value in the analysis of giant uterine leiomyomas, which can observe the size, location, complicated with hematoma, necrosic,or cystis degeneration or not, and the relationship with the surrounding organs of giant uterine leiomyomas, which may be the guidance for surgical treatment.