Objective To analyze the diagnostic effect of CT perfusion combined with CT angiography in patients with ischemic stroke, and to provide scientific data for the treatment of ischemic stroke patients. Methods Selection of our hospital in March 2015- 2016 February treated ischemic cerebral stroke in patients with clinical data of 28 cases, by spss21.0 statistical software for statistical analysis of the two kinds of inspection methods for patients of cerebral perfusion abnormalities, intracranial vascular stenosis and consistent with a diagnosis of. Results Agent/100g respectively were abnormal perfusion of cerebral blood volume, contrast agent peak time, cerebral blood flow, contrast agent mean through time (4.26+0.54)/100g, (251600+3.22)s, (39.66+15.23)/100g·min, (5.23+0.67)s, the mirror area of cerebral blood volume, contrast agent peak time, cerebral blood flow, contrast agent mean through time (5.35+0.84)/100g, (24.91+3.23)s, (56.24+15.61)- min, (4.01 and 0.68)s, cerebral blood volume, cerebral blood flow, contrast agent mean through time compared with statistical significance (P<0.05), compared to the peak time is no statistical significance (P>0.05). The joint inspection results: 28 cases of patients with vascular responsibility for 4 cases, the positive rate was 14.26% (4/28), 28 cases of responsible vessels for 20 cases of the patients does not exist, the positive rate is 71.43% (20/28), the examinations of the two groups the difference has statistical significance (P<0.05). Conclusion CT perfusion combined with CT angiography in the diagnosis of ischemic stroke patients can provide more useful information to accurately reflect the changes in cerebral hemodynamics, to provide a reference for clinical diagnosis.