Objective To explore the spiral CT gastric mucosa imaging technology, to determine the best gastric mucosa spiral CT scanning imaging program. Methods Step 1:60 people were randomly divided into three groups. 20 people in each group were randomly divided into three groups. The optimal arterial period was determined by using the same dose and the same injection speed of 80ml (3ml/s) with different arterial stages: early (18s), middle (25s) and late (30s). Step 2: the remaining 100 people were randomly divided into five groups, and each group was divided into 5 groups. The optimal time of the early trial was divided into 5 groups, with different doses and infusion speed: 60ml (3ml/s), 60ml (4ml/s), 80ml(4ml/s), 100ml(3ml/s) and the optimal time group in the early trial of 80ml(3ml/s). Results There were 18 cases (90%) with good scanning effect at middle stage (25s) of the first step, which was significantly higher than 5 cases (25%) in early stage (18s) and 6 cases (30%) in late stage (30s) (P=0.045(P<0.05). Step 2 middle arterial (25s)80ml (3ml/s) effect of 18 cases (90%) was significantly different from other groups with different contrast dose and contrast agent injection speed (P=0.0065(P<0.01). Conclusion The optimal imaging scheme for spiral CT scanning of gastric mucosa is: arterial phase (25s), contrast dose (80ml), and contrast infusion speed (3 ml/s).