Objective To compare the diagnostic values of transabdominal ultrasound (TAS) and transvaginal ultrasonography (TVS) in cornual pregnancy. Methods 60 suspected cornual pregnancy patients treated in our hospital from January 2015 to December 2016 were selected as the research objects, and all these patients were given TAS, TVS and operative examinations. The results of operative examination were taken as the gold standard, and the diagnostic accuracy rates of TAS and TVS in detection of cornual pregnancy were evaluated. Results The total diagnostic accuracy rate of TVS was 81.67% (49/60), and the diagnostic accuracy rate of TVS in detection of cornual pregnancy was 85.19% (46/54), the total diagnostic accuracy rate of TAS was 63.33% (38/60), and the diagnostic accuracy rate of TAS in detection of cornual pregnancy was 64.91% (35/54), the total diagnostic accuracy rate and the diagnostic accuracy rate of cornual pregnancy of TVS were higher than those of TAS (χ2 =5.058, P=0.0245; χ2 =5.975, P=0.015). Conclusion Comapred with TAS, TVS which has higher diagnostic accuracy rate of cornual pregnancy, can better differentiate different disease types, thus, it has higher clinical value.