Objective To anlyze the effect of PDCA cycle management on nursing quality in gynaecology and obstetrics operating room. Methods 21 nursing staff in Luoyang women and children medical care center were taken as the research objects. 143 patients accepted gynecological surgery from Apr. 2015 to Apr. 2016 were given routine surgical management (before PDCA implementation), and another 143 patients accepted gynecological surgery from Apr. 2016 to Apr. 2017 were given PDCA cycle management (after PDCA implementation). The nursing quality, nursing satisfaction degrees and incidence rates of adverse events in the two groups were compared before and after PDCA implementation. Results After the implementation of PDCA, the improvement of basic nursing quality, grading nursing quality, quality of nursing skills, quality of nursing records and quality of health education was better than that before the implementation of PDCA (P<0.05), the satisfaction degrees of coordination between doctors and nurses and nursing satisfaction degrees were all higher than those before the implementation of PDCA (P<0.05), the incidence rates of adverse events of intraoperative equipment shortage, operation fee miscalculation, foreign body residue, missed physician order, drug extravasation, transfusion reaction, sharp instrument injury and error medication in the two groups during the perioperative period were lower than those before the implementation of PDCA (P<0.05). Conclusion PDCA cycle management can significantly improve the quality of nursing in gynecology and obstetrics operating room and the work efficiency of nursing staff, increase the satisfaction of doctors and patients, and ease the tension between doctors and patients.