Objective To explore the application effects of situational interaction model on the health education of patients in ophtalmology department. Methods 120 cases of patients in ophtalmology department from Jan. 2016 to Dec. 2016 were randomly divided into observation group (60 cases) and control group (60 cases) according to the random number table method. Control group was given health education in the normal mode, and observation group was given health education in the situational interaction model. The awareness rate of health education and the psychological states before and after intervention [medical coping mode questionnaire ( MCMQ) and anxiety visual analogue test (AVAT)] were also compared between the two groups. Results After intervention, the awareness rate of health education in observation group was better than that in control group (P<0.05). The scores of avoidance subscale and AVAT in the two groups were all significantly lower than those before intervention (P<0.05), and the scores of facing subscale in the two groups were all significantly higher than those before intervention (P<0.05), and the change ranges in observation group were greater than those in control group (P<0.05). There was no significant difference in yield subscale score between the two groups and within-groups before and after intervention (P>0.05). Conclusion Health education in situational interaction model is helpful to improve the cognitive level of ophthalmic patients, and it can reduce the anxiety degree and make patients respond more actively to disease states.