Objective To explore the detection value of platelet parameters and coagulation indexes in cirrhosis patients with hemorrhage. Methods The clinical data of 304 cirrhosis patients and 152 healthy persons from January 2016 to January 2017 were retrospectively analyzed. Among these people, 152 cirrhosis patients with hemorrhage were divided into hemorrhagic tendency group, another 152 cirrhosis patients without hemorrhage were divided into non-hemorrhagic tendency group, and 152 healthy volunteers were divided into healthy group. The differences of platelet parameters [platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW)] and coagulation indexes [prothrombin time (PT), thrombin time (TT), active part thrombin time (APTT), fibrinogen (FIB), antithrombin III (AT-III) and D-dimer (DD)] in the three groups were compared. Results The levels of PLT and PCT in the two cirrhosis groups were lower than those in the healthy group (P<0.05), the levels of MPV and PDW in the two cirrhosis groups were higher than those in the healthy group (P<0.05), and the change ranges of platelet parameters in the hemorrhagic tendency group were greater than those in the non-hemorrhagic tendency group(P<0.05), the levels of PT, TT, APTT and DD in the two cirrhosis groups were higher than those in the healthy group(P<0.05), the levels of FIB in the two cirrhosis groups were lower than those in the healthy group (P<0.05), and the change ranges of coagulation indexes in the hemorrhagic tendency group were greater than those in the nonhemorrhagic tendency group(P<0.05), the AT-III detection results showed that healthy group>hemorrhagic tendency group>non-hemorrhagic tendency group (P<0.05). Conclusion Platelet parameters and related coagulation indexes which are conducive to early diagnosis and treatment, can not only directly reflect the tendency of bleeding, but also indirectly reflect the degree of liver damage in patients with cirrhosis.