Objective To observe the effect of tigerrillo on arterial inflammatory response and platelet parameters in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods 83 ACS patients who received PCI in our hospital from October 2015 to October 2017 were selected as objects, which were divided into experimental group and control group according to different postoperative treatment methods. 42 patients in the experimental group were treated with tigerrillo after surgery, and 41 patients in the control group were treated with clopidogrel after surgery. Changes in hypersensitive C response protein (hs-crp), interleukin 6(il-6), soluble leukocyte differentiation antigen 40 ligand (sCD40L), platelet count (PLT), P2Y12 response unit (PRU) levels and adverse drug response rates were compared between the two groups 24 hours after surgery and three months after drug treatment. Results The hs-crp, il-6, sCD40L, PLT and PRU levels of the two groups before treatment showed no significant difference (P>0.05), and the hs-crp, il-6, sCD40L, PLT, PRU levels and adverse reaction rates of the experimental group after treatment were significantly lower than those of the control group (P<0.05). Conclusion The treatment of ACS patients after PCI by tigerrillo can effectively reduce the arterial inflammatory reaction of patients, reduce the level of PLT and PRU in patients, and the incidence of adverse reactions is small, which has certain clinical value.