Objective Intramural pregnancy (IMP), a very rare type of ectopic pregnancy, was only reported around 100 cases globally in published literature, though an increase of incidence was observed recently. Methods We summarized the clinical data of 3 cases of intramural pregnancy treated in our hospital with respect to aetiology, diagnosis and management. Results Two of the 3 cases underwent in vitro fertilization/embryo implantation. Two had the history of abortion, one of whom had experienced multiple times. All these 3 cases were misdiagnosed of cornual pregnancy by B Ultrasound. Testing of β-HCG failed to provided evidence to distinguish IMP from intrauterine pregnancy. All 3 cases underwent laparoscopic surgery with satisfied outcome. Conclusion The awareness of IMP should be raised due to the increased incidence. The etiology was still unclear, the most acceptable perception could be the consequence of previous uterine surgery, such as a caesarean section or myomectomy, in vitro fertilization/embryo implantation, or repeated abortion. Although it was difficult to differentiate from cornual pregnancy, an earlier laparoscopic surgical intervention would be an appropriate choice for diagnose and appropriate management.