Objective To observe the curative effect of small doses of Torrimifen citrate joint Xiaoru Sanjie capsules in the treatment of male breast hypertrophy. Methods A retrospective analysis in January 2015 to June 2017 clinical data of 100 patients with male breast hypertrophy,the observation group of 50 cases, by using small dose of Torrimifen citrate joint Xiaoru Sanjie capsules treatment, the control group, 50 cases with alone Xiaoru Sanjie capsules treatment, compare the treatment effect of the two groups, the incidence of adverse reactions and two groups of patients before and after the treatment estradiol, testosterone, prolactin level changes. Results The total effective rate of treatment was 95% in the observation group, and the total effective rate of treatment was 82% in the control group. The total effective rate of patients in the observation group was significantly higher than that in the control group (P<0.05). The adverse reaction rate was 14% in the observation group and 26% in the control group. The observation group was lower than the control group (P<0.05). The control group after treatment estradiol, testosterone levels lower than before treatment (P<0.05), testosterone levels after treatment group is lower than before treatment (P<0.05). After treatment, the level of estradiol and prolactin was lower than that in the control group (P<0.05). Conclusion Small dose of Torrimifen citrate joint Xiaoru Sanjie capsules in the treatment of male breast hypertrophy, therapeutic effect is remarkable, can effectively alleviate the patient's clinical symptoms, and lower incidence of adverse reactions, is worth popularizing in clinical.