Objective To comprehensively analyze the anesthetic effect of sufentanil combined with ropivacaine in primary women. Methods A total of 80 first-time mothers (full-term single fetuses) treated in our hospital were selected as study objects, and randomly divided into experimental group (using sufentanil combined with ropivacaine anesthesia) and control group (using sufentanil anesthesia) according to the digital randomization table, with 40 cases in each group. SPSS20.0 statistical software was used for statistical analysis of the onset time of analgesia, duration of analgesia, incidence of adverse reactions (nausea and vomiting, pruritus of the skin), and visual pain scores before and after anesthesia for first-time mothers in the two groups. Results The onset time of analgesia in the experimental group was significantly shorter than that in the control group (P<0.05), the duration of analgesia in the experimental group was significantly longer than that in the control group (P<0.05), and the incidence of adverse reactions including nausea, vomiting and pruritus in the experimental group was significantly lower than that in the control group (P<0.05). Before anesthesia, the visual pain scores of the two groups were not statistically significant (P>0.05), and the visual pain scores of the two groups were decreased at 10min after anesthesia (P<0.05), while the visual pain score of the experimental group was significantly lower than that of the control group (P<0.05). Conclusion The efficacy of sufentanil combined with ropivacaine was better than that of sufentanil alone.