Objective To explore the effect of early nosocomial and comprehensive rehabilitation training on improving children with cerebral palsy (CP). Methods From Jan. 2015 to Dec. 2016, 60 CP children whose clinical data were retrospectively analyzed were taken as the research objects, and they were divided into study group (n=30) and control group (n=30). The study group was given early nosocomial and comprehensive rehabilitation training, while the control group was given familial rehabilitation nursing. The curative effects in the two groups were observed, and the motor function [Gross Motor Function Measure ( GMFM)] and development of children [Bayley Scale of Infant Development (BSID)] in the two groups were evaluated before and after treatment. Results 6 months after treatment, the excellence rate and total effective rate in the study group were all significantly higher than those in the control group (P<0.05), the GMFM score and motor development in the two groups were all significantly increased (P<0.05), and the increase in the study group was significantly higher than that in the control group (P<0.05), the intragroup and intergroup differences were not statistically significant (P>0.05). Conclusion Early nosocomial and comprehensive rehabilitation training which is more favorable for children's motor development, can significantly improve their gross motor function.