Objective To investigate the clinic effect of amisulpride and risperidone in treatment of first episode schizophrenic patients. Methods 60 cases with first episode schizophrenic in The Fourth People's Hospital of Jiaozuo from March 2016 to March 2017 were selected and divided into observation group (n=30) and control group (n=30), According to the admission order, the single number is divided into the study group (n=30), and the double number is the control group (n=30), clinic effect of the two groups was compared and PANSS of the two groups before and after treatment was objectively evaluated. Results After comparison, The total clinical efficiency of the study group and the control group was 76.67% and 66.66%, respectively, with no statistically significant difference (P>0.05). 2, 4 8 weeks after treatment, PANSS score of study group was better than control group and that before treatment,but P>0.05 was not statistically significant. Conclusion Amisulpride and risperidone has same clinic effect on treatment of first episode schizophrenic patients, but amisulpride can improve negative symptoms and depressive symptoms better.