Objective To compare the clinical efficacy of minimally invasive surgery with intracerebral hemorrhage and catheter aspiration in the treatment of elderly patients with cerebral hemorrhage. Methods 68 patients with cerebral hemorrhage were selected as the clinical subjects from December 2015 to December 2016. According to the admission time, the patients were numbered 01 to 68, and double patients as the control group, single patient as the test group. 34 patients in the control group were treated with traditional craniotomy. 34 patients in the experimental group were treated with minimally invasive cerebral hemorrhage and catheterization. The neurological function and quality of life were compared in all patients. Results The neurological function score in the control group was significantly higher than that in the experimental group after treatment with different surgical methods. The physical function of the patients in the control group, the physiological function, the mental health, the emotional function, which were significantly lower than the experimental group, the difference were statistically significant (P<0.05). Conclusion The combination of minimally invasive cerebral hemorrhage surgery and catheterization surgery in the treatment of elderly patients with cerebral hemorrhage compared with traditional craniotomy treatment methods, higher safety, little impact on neurological function, postoperative recovery is better,it is worth Widely used in clinical practice.