Objective To analyze the clinical efficacy of nursing patients treated with external fixation of long bone fractures. Methods From June 2006 to June 2017, 80 patients with long tubular fractures who underwent clinical diagnosis and treatment were treated with external fixation and grouped according to different nursing methods. The patients in the control group were treated with routine Nursing group, The patients in the experimental group with nursing intervention, compared the two groups of patients with different nursing methods with the clinical efficacy of treatment. Results After treatment, the total effective rate (97.50%) in the experimental group was significantly higher than that in the control group (67.50%). The adverse reaction rate in the control group (35.00%) was significantly higher than that in the experimental group (2.50%),the difference was statistically significant(P<0.05). Conclusion Nursing intervention in patients with long tubular fractures treated with external fixation can effectively improve the clinical curative effect and promote the recovery of patients, and have high clinical application value.