Objective The study was to discuss the effect of the application of doctor-therapist-nurse mode in the clinical pathway for total knee arthroplasty. Methods 150 patients were divided into the test group, the first control group and the second control group. The test group was carried out clinical pathway by the integrated therapy process under doctortherapist-nurse mode. While the first and the second control group was practised the routine nursing and the clinical pathway nursing respectively. Then, the incidence of postoperative complication, the hospital for special surgery knee score (HSS), the hospital stay, the hospital charge (except the artificial prosthesis), and the patient satisfaction were compared among the three groups. Results The second control group was lower than the first control group but higher than the test group in the incidence of postoperative complication, the hospital stay and the hospital charge obviously (P<0.05). The HSS had no difference among the three groups preoperatively (P>0.05), however, it was evident that the second control group got a higher score than the first control group but lower than the test group postoperatively (P<0.05). The second control group was higher than the first control group but lower than the test group in the patient satisfaction obviously (P<0.05). Conclusion The doctor-therapist-nurse mode could shorten the hospital stay, reduce the hospital charge, prevent the incidence of postoperative complication, promote the functional recovery and improve the satisfaction in total knee arthroplasty, which is a worth spreading mode.