Objective To study the influence of positive suggestion of medical and nursing integration on negative emotions and prognosis effects in patients undergoing fracture surgery. Methods 196 fracture patients undergoing selective operation in our hospital were randomly divided into experimental group (98 cases) and control group (98 cases). The control group was given routine nursing, while the experimental group was given medical and nursing integration combined with positive suggestion nursing. The negative emotions, intraoperative physiological indicators and nursing satisfaction were compared between two groups. Results After intervention, the SAS and SDS scores in the two groups were all significantly decreased (P<0.05), and the decrease in the experimental group was more than that in the control group (P<0.05), the fluctuation range of intraoperative blood pressure and heart rate in the experimental group was significantly lower than in the control group (P<0.05), the nursing satisfaction in the experimental group was significantly higher than that in the control group (P<0.05). Conclusion The positive suggestion of medical and nursing integration can effectively resolve the negative emotions of patients with fracture, reduce the fluctuation of blood pressure and heart rate during operation, and improve the satisfaction of family members. Thus, it is worthy of clinical promotion.