Objective To evaluate the effect of predictive nursing intervention on acute pressure ulcer formation in Department of orthopedics. Methods 200 cases of operation patients from October 2014 to February 2016 in our hospital were randomly divided into two groups according to the excel table: routine nursing intervention mode (routine nursing group, 100 cases) and the nursing care intervention (predictive nursing group, 100 cases), the incidence of pressure ulcers, pressure ulcers and nursing satisfaction rate of the two groups were compared. Results The results showed that the incidence of pressure sores and the incidence of pressure ulcers in the predictive nursing group were significantly lower than those in the conventional nursing group(P<0.05). The satisfaction degree of the patients in the foreseeable nursing group was higher than that of the conventional nursing group(P<0.05). Conclusion The implementation of predictive nursing mode in Department of orthopedics patients with different stages can effectively reduce the incidence of pressure sores and the incidence of patients, improve the satisfaction rate of patients, it is worthy of clinical application.