Objective To observe the curative effect and safety of Oseltamivir combined with Yanhuning on children with virus pneumonia (CVP). Methods 890 children with CVP were randomly divided into observation group (452 cases) and control group (438 cases). The observation group was treated with oseltamivir combined with Yanhuning, while the control group was given Yanhuning antiviral therapy. The differences of clinical efficacy, main symptoms and signs disappearance time between the two groups were observed, and the incidence of adverse reactions was recorded. Results The total effective rate in the observation group was significantly higher than that in the control group (P<0.05), the disappearance time of main clinical symptoms and signs (fever, cough, shortness of breath and rales) in the observation group was significantly shorter than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Oseltamivir combined with Yanhuning therapy which has less adverse reactions, can not only improve clinical curative effect of children with CVP, but also shorten their remission time of related symptoms.