Objective To investigate and analyze the chronic pulmonary heart disease (CPHD) patients with serum N terminal B type natriuretic peptide (NT-pro BNP) and high sensitive C reactive protein (Hs-CRP) clinical value. Methods The study selected October 2016 -2017 year in August in the 36 CPHD patients in our hospital as the object of study, follow the patients were divided into group A, group B, 18 cases in each group. The group of patients with simple CPHD, group B patients with CPHD complicated with chronic obstructive pulmonary disease (CODP), and evaluation of two groups of patients with NT-pro BNP level, Hs-CRP level, PaO2 (arterial oxygen partial pressure (PaCO2) level. Arterial partial pressure of carbon dioxide). Results The group of patients with NT-pro BNP level, PaCO2 level lower than that of group B patients, the difference was statistically significant. Compared with the group of patients with PaO2 was higher than group B patients, the difference was statistically significant compared. Conclusion NT-pro BNP level, Hs-CRP level for COPD Patients with CPHD have important differential significance. When COPD patients are combined with CPHD, the levels of NT-pro, BNP and Hs-CRP are obviously increased, which is related to hypoxia.