Objective To study the the test significance of procalcitonin (PCT) and C- reactive protein (CRP) for early infection in patients with severe multiple injuries. Methods From Jun. 2013 to Jun. 2015, a total of 64 patients with severe multiple injuries in our hospital were taken as the clinical research objects, and they were divided into observation group (32 cases, infection) and control group (32 cases, uninfection). After admission, tests of PCT and CRP serum levels in these two groups were made at different time in order to find their clinical value for early infection in patients with severe multiple injuries by comparing the changes of PCT and CRP serum levels and the positive rates of PCT and CRP. Results 5 and 7 days after admission, the CRP levels in the observation group were respectively (157.82±42.38)mg/ L and (167.82±40.23)mg/L which were significantly higher than those in the control group (108.64±32.11)mg/L and (112.30±28.93)mg/L (P<0.05), the serum levels of PCT showed an upward tendency in these two groups as time went on. 5 and 7 days after admission, the PCT levels in the observation group were respectively (29.73±17.64)ng/mL and (36.58±12.64)ng/mL which were significantly higher than those in the control group (1.55±0.27)ng/mL and (1.63±0.37) ng/mL (P<0.05). 1 week after admission, the positive rates of PCT and CRP in the observation group were respectively 93.75% and 90.63% which were significantly higher than those in the control group 12.50% and 18.75%(P<0.05). Conclusion The early infection can cause abnormal increase of PCT and CRP serum levels in patients with severe multiple injuries. Therefore, the test of PCT and CRP serum levels in patients with severe multiple injuries has a certain value to determine whether the early infection exists.