Objective To investigate the internal carotid artery stenosis stenting factors postoperative reperfusion injury in shape. Methods In our hospital from January 2014 to March 2016 35 hospitalized patients with carotid artery stenosis stenting in patients undergoing shaping as a research object. In accordance with internal carotid artery stenosis as severe stenosis group and 15 cases of 20 patients with moderate stenosis. Two groups of patients were treated with internal carotid artery stenosis stent angioplasty, the two groups after statistical probability of reperfusion injury and influencing factors. Results The rate of reperfusion injury in patients with severe stenosis was significantly higher in patients, the difference was statistically significant (P<0.05). Internal carotid artery stenosis stenting angioplasty main factors of postoperative reperfusion injury incidence for age, comorbidities and stenosis patients. Conclusion Based on the internal carotid artery stenosis stent angioplasty reperfusion injury risk of the occurrence of postoperative factors and statistical analysis, patient age, comorbidities and other factors stenosis greater chance of postoperative reperfusion injury affected.