Objective To probe the clinic and imaging features of solitary enchondroma in long bone of limbs. Methods Clinic and imaging date of 12 patients with solitary enchondroma in long bone of limbs confirmed by surgical pathology were analyzed retrospectively. Results All patients had been underwent X-ray film. Calcification only in 2 cases, bone destruction only in 1case, and bone destruction with calcification in 9 cases. CT was performed in 8 cases and all cases showed bone destruction with varying calcification inside the lesions. CT was optimal to detect the minor destruction of bone and slight calcification. 7 cases were received MRI examination. All cases were hypointense on T1WI mainly, with stippling high signal intensity on T1WI in 1 case, and significantly high signal intensity on T2WI. On post contrast images, 4 cases showed “ring-and-arc” like heterogeneous enhancement and 3 plaque-like heterogeneous enhancement. There were no periosteal reaction and soft-tissue mass on all imaging finds. Conclusion Most of the solitary enchondroma in long bone of limbs had typical imaging features, the qualitative and differential diagnosis of which can be made mostly by X-ray film, CT and MRI.