Objective Further understanding the epidemiologic features of pregnancy combined measles, the clinical manifestation, the maternal-fetal adverse effects, and the prognosis. Methods A retrospective study was performed on 46 cases of pregnancy combined measles during January 2012 to December 2014, the analysis was emphasized on both maternalfetal effects and its prognosis. Results 22 of 46 cases were in first and second trimester, the other 24 cases were third trimester pregnancy. 9 of the 22 (19.5%) ended in miscarriage or still birth. 1 premature delivery, 8 c-section and 2 neonatal measles were observed among the 24 late pregnancy patients. Conclusion Viral effects on nervous system may increase the possibility of miscarriage in first and second trimester when maternal infection happens in early pregnancy. Contracting in second and third trimester may lead to still birth and premature delivery. Active intervention is suggested to be given from second trimester to diminish the complication, still birth and premature birth.