Objective To analyze the clinical effect of small incision appendectomy for appendicitis. Methods From Jun. 2013 to Jun. 2014, a total of 84 patients with appendicitis were selected in our hospital, and they were randomly divided into observation group (42 cases) and control group (42 cases). Patients in the control group were given conventional appendectomy, the other patients in the observation group were given small incision appendectomy. After treatment, the clinical effects of these two groups were evaluated. Results The indicators such as operation time, intra-operative blood loss, incision length, and hospitalization time of the observation group were significantly lower than those of the control group(P<0.05), the incidences of intestinal fistula, intestinal obstruction, subcutaneous emphysema and infection in the observation group were also significantly lower than those in the control group(P<0.05), and their differences were statistically significant. Conclusion For patients with appendicitis, small incision appendectomy which can improve the clinical effects has advantage of less trauma, less bleeding, fewer complications and shorter hospitalization time . Thus, it is worthy of clinical application.