Correlative Study of MRI Features and Expression of bcl-2, p53 in Breast Carcinoma*
Author：LI Gang, ZENG Zhong-gang, QIN Da-xian, et al.
affiliation：Department of Radiology, Dongguan Tung Wah Hospital Affiliated of Sun Yat-sen University, Dongguan 523110, Guangdong Province, China
PDFAbstract
Objective To investigate the relationship between MRI features and expression of bcl-2, p53 in breast carcinoma. Methods In 25 cases with breast cancer and 26 cases of benign breast tumor patients with preoperative MRI examination (plain scan, DWI and enhanced), MRI findings of lesions, such as morphology, edge, early intensive, ADC value, enhancement curve type and lymph node metastasis were analyzed.the immunohistochemical (S-P) method was used to test the expression of bcl-2, p53 in postoperative samples, then analyzed the relationship of MRI features and expression of bcl-2, p53 of the lesions. Results The MRI features of breast cancer (irregular or burr shape, lower ADC, enhancement curve and type II and III, lymph node metastasis) were significantly negatively correlated with the expression of Bcl-2 (P<0.01),and significantly positively correlated with the expression of p53 (P<0.01). Conclusion MRI signs of breast cancer is closely correlated with the expression of bcl-2, p53, may indirectly reflect certain molecular biological characteristics of breast cancer, help to guide the clinical treatment and prognostic evaluation.
【Keyword】Breast Cancer; MRI; Bcl-2, p53
【Chart number】R737.9
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2016.01.006
Journal of Rare Diseases
th23Volume， th 1 Issue
2019Year11Month
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